Here Mudassar Ahmed Khan has explained with an example, how to avoid (Prevent) Page refresh (reload) after SelectedIndexChanged is fired in ASP.Net DropDownList using C# and VB.Net.
The only possible way is to place the DropDownList inside ASP.Net AJAX UpdatePanel so that, instead of Full PostBack which causes Page refresh (reload), a Partial PostBack will occur.
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Avoid (Prevent) Page refresh (PostBack) after SelectedIndexChanged is fired in ASP.Net DropDownList
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